Microwavephysics and Atmospheric Physics
Biomedizinische Photonik
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HS 2015  ·  FS 2015
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HS 2011  ·  FS 2011
Ultrafast Science and Technology
Last update: 18.10.2017
FS 2014: Seminare über Biomedizinische Photonik
Wednesday 10-12
Vorträge, die innerhalb der nächsten Tage stattfinden, sind speziell markiert.
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Mittwoch, 14.05.2014

The photon diffusion coefficient (retrieving the diffusion model from the random walk picture)

Zeit: 10:15 Uhr
Hörsaal: A97
 
Dr. Günhan Akarçay
Institute of Applied Physics
University of Bern

 
Mittwoch, 21.05.2014

Computed ultrasound tomography in echo-mode: successes and challenges

Zeit: 10:15 Uhr
Hörsaal: A97
 
Dr. Michael Jaeger
Institute of Applied Physics
University of Bern

 
Freitag, 23.05.2014

Restoration of Sight with Photovoltaic Subretinal Prosthesis

Zeit: 10:15 Uhr
Hörsaal: A97
 
Prof. Daniel Palanker, Department of Ophthalmology and Hansen Experimental Physics Laboratory
Stanford University, Stanford, CA

Retinal degeneration leads to blindness due to gradual loss of photoreceptors. Information can be reintroduced into the visual system by patterned electrical stimulation of the remaining retinal neurons. Photovoltaic subretinal prosthesis directly converts light into pulsed electric current in each pixel, stimulating the nearby inner retinal neurons. Visual information is projected onto the retina by video goggles using pulsed near-infrared (~900nm) light.
Subretinal arrays with 70µm photovoltaic pixels provide highly localized stimulation: retinal ganglion cells respond to alternating gratings with the stripe width of a single pixel, which is half of the native resolution in healthy controls (~30µm). Similarly to normal vision, retinal response to prosthetic stimulation exhibits flicker fusion at high frequencies (>20 Hz), adaptation to static images, and non-linear summation of subunits in the receptive fields. In rats with retinal degeneration, the photovoltaic subretinal arrays restore visual acuity up to half of its normal level (~1 cpd), as measured by the cortical response to alternating gratings. If these results translate to human retina, such implants could restore visual acuity up to 20/250. With eye scanning and perceptual learning, human patients might even cross the 20/200 threshold of legal blindness. Ease of implantation and tiling of these wireless modules to cover a large visual field, combined with high resolution opens the door to highly functional restoration of sight.

 
Mittwoch, 28.05.2014

Experimental determination of optical effective attenuation for fluence compensation in OA imaging

Zeit: 10:15 Uhr
Hörsaal: A97
 
Gerrit Held
Institute of Applied Physics
University of Bern

 
Mittwoch, 04.06.2014

Optoacoustic microscopy - SNF international short visit

Zeit: 10:15 Uhr
Hörsaal: A97
 
Dr. Pavel Subochev
Institute of Applied Physics
University of Bern

 
Mittwoch, 11.06.2014

Master thesis presentation: Accurate determination of vapour bubble radii in stalagmite fluid inclusions

Zeit: 10:15 Uhr
Hörsaal: A97
 
Florentin Spadin
Institute of Applied Physics
University of Bern

 
Donnerstag, 19.06.2014

Cochlea implantation: Using laser light for bone drilling and nerve stimulation

Zeit: 15:15 Uhr
Hörsaal: A97
 
Arushi Jain
Institute of Applied Physics
University of Bern

 
Freitag, 27.06.2014

Raman spectroscopy of synthetic fluid inclusions (water) in quartz

Zeit: 09:15 Uhr
Hörsaal: A97
 
Chen Qiu
Institute of Applied Physics
University of Bern

 
Mittwoch, 13.08.2014

Combination of optoacoustic imaging and diffuse optical tomography for cerebral oxygenation map in preterm neonates

Zeit: 10:15 Uhr
Hörsaal: A97
 
Parisa Farzam
The Institute of Photonic Sciences (ICFO)
Barcelona, Spain

Noninvasive measurement of hemodynamics at the microvascular level may have a great impact on oncology in clinics for diagnosis, therapy planning and monitoring, and, in pre-clinical studies. To this end, diffuse optics is a strong candidate for noninvasive, repeated, deep tissue monitoring. In this multi-disciplinary, translational work, I have constructed and deployed hybrid devices which are the combination of two qualitatively different methods, near infrared diffuse optical spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS), for simultaneous measurement of microvascular total hemoglobin concentration, blood oxygen saturation and blood flow.

In a pre-clinical study, I applied the hybrid device to monitor the response of renal cell carcinoma in mice to antiangiogenic therapy. The results suggest that we can predict the output of therapy from early hemodynamic changes, which provide us with valuable information for better understanding of the tumor resistance mechanism to antiangiogenic therapies.

In two in-vivo studies in human volunteers, I have developed protocols and probes to demonstrate the feasibility of noninvasive diffuse optical spectroscopy to investigate the pathophysiology of bone. First study was study on the physiology of the patella microvasculature, the other introduced the manubrium as a site that is rich in red bone marrow and accessible to diffuse optics as a potential window to monitor the progression of hematological malignancies.

I will present the instrumentation, theory and algorithms and protocols as a transition between pre-clinical and clinical studies and describe how this work will lead to new applications in oncology.