Microwavephysics and Atmospheric Physics
Biomedizinische Photonik
HS 2017  ·  FS 2017
HS 2016  ·  FS 2016
HS 2015  ·  FS 2015
HS 2014  ·  FS 2014
HS 2013  ·  FS 2013
HS 2012  ·  FS 2012
HS 2011  ·  FS 2011
Ultrafast Science and Technology
Last update: 13.09.2017
FS 2013: Seminare über Biomedizinische Photonik
Wednesday 10-12
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Donnerstag, 14.03.2013

Time-resolved luminescence technique: probes, instruments, and biomedical applications

Zeit: 15:15 Uhr
Hörsaal: A97
 
Yiqing Lu
Dept. Physics
Macquarie University
Sydney, NSW 2109
Australia

There are major issues arising from the complex nature of biomolecules. The current fluorescence methods differentiate analytes by colours, considerably limiting the total number of species to be detected simultaneously and the throughput of biodetection. The intrinsic autofluorescence from non-target organisms also interferes with the visibility of targeted organisms, especially when detecting trace amounts of agents within complex samples. Time-Resolved Luminescence (TRL) technique has been proposed to explore the temporal domain in order to break through these limitations. In this talk, I will to summarize our recent progress in probes, instruments as well as biomedical applications associated with TGL technique. We developed three types of rare-earth nanoparticles capable of tuning luminescence lifetimes, ideal for multiplexed and background-free biosensing. These nanoparticles were characterized and applied in our purpose-built orthogonal scanning automated microscopy, time-resolved confocal microscopy/spectroscopy, and 3-D flow cytometry, which we implemented for rare-event pathogen detection, quantitative analyses of cell surface antigens, and multiplexed biodetection either using nanoparticle biolabels or suspension arrays. We believe this will lead to a powerful platform for bioinformatic discovery, environmental screening, pharmaceutical development, and biomedical diagnoses.

 
Mittwoch, 24.04.2013

Image based determination of optical attenuation for fluence compensation in optoacoustic imaging

Zeit: 16:15 Uhr
Hörsaal: B116
 
Stefan Preisser
Institute of Applied Physics
University of Bern

Optoacoustic (OA) imaging allows the detection of absorbing structures inside the human body, based on the ultrasound that is generated upon the thermalization of absorbed light when irradiating the tissue with short laser pulses. In spectral OA imaging, differences in the absorption spectra of oxy- and deoxyhaemoglobin can be used for imaging the blood oxygenation in a multi-wavelength approach. For the correct interpretation of the spectral slope of the signal, knowledge of the wavelength-dependent fluence is required (fluence compensation).

I will present our current research on a novel method that in principle allows determining the effective attenuation coefficient based on the OA image itself, without any a priori knowledge and in real-time. This method is promising for fast fluence compensation for more accurate spectral OA imaging as a novel functional modality combined with real-time diagnostic ultrasound.

 
Dienstag, 18.06.2013

Präsentation der Bachelorarbeiten

Zeit: 15:15 Uhr
Hörsaal: A97
 
Larissa Frey,
Jonas Hagen,
Andreas Peter
Institut für Angewandte Physik
Universität Bern

Dynamische Lichtstreuung zur Grössenbestimmung von Porphyrinen - Larissa Frey

Evaluation digitaler Mikrospiegel als Fluidiksystem - Jonas Hagen

Transport und Selbstorganisation in einem Computermodell für Zilienfelder - Andreas Peter